RAF Typhoon jets have joined forces with France's air force in a combined operation against an underground arms cache in Syrian territory used by the IS group, according to the UK Ministry of Defence.
The location, pinpointed through reconnaissance, was assessed as containing munitions and bombs, the announcement noted, and was located in mountains just above the historic site of Palmyra in central Syria.
"The RAF jets employed laser-guided Paveway IV weapons to target a series of entry passages leading to the site... early reports suggest the strike was effective," the ministry announced.
There was no indication of any civilian impact in the strike late on Saturday and every plane involved returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
Daesh - also known as the so-called Islamic State - established jihadist rule over parts of Iraq and Syria until 2019.
"This strike underscores British leadership, and resolve to stand shoulder to shoulder with our partners, to eradicate any resurgence of the terrorist group and their dangerous and violent ideologies in the region," Britain's Defence Chief John Healey stated.
British military aircraft have carried out overwatch operations over Syria to "forestall any attempted resurgence" of Islamic State after its routing at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces involved in this strike for their professionalism and their courage," Healey commented. "Including them were numerous British troops on duty over the holidays. This action, to remove dangerous terrorists who threaten our way of life, demonstrates how our armed forces are prepared to act, throughout the year, keeping Britain secure within its borders and powerful internationally."
In December, the American forces executed what it called a "large-scale strike" on IS targets in the country, following an attack killed two US troops and a local interpreter in the Palmyra area.
The United Nations reports IS still boasts between 5,000 and 7,000 fighters in both countries.